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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor family C group 6 member A
Species	Mus musculus (Mouse)
Gene	Gprc6a
Synonym	G protein-coupled receptor G protein-coupled receptor, class C, group 6, member A G protein-coupled receptor, family C, group 6, member A GPCR6A GPRC6 receptor
Disease	N/A for non-human GPCRs
Length	928
Amino acid sequence	MALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTSSFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTIENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVLKNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQETKHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCNNETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVVKSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVIILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVYNYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTIKASKTLRQKRSSSI
UniProt	Q8K4Z6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3347255
IUPHAR	55
DrugBank	N/A

Ligand

Name	CHEMBL3633662
Molecular formula	C22H23N3O3
IUPAC name	2-[(2-morpholin-4-yl-2-oxoethyl)amino]-1-(2-phenyl-1H-indol-3-yl)ethanone
Molecular weight	377.444
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.2
Synonyms	BDBM50133684
Inchi Key	CTJPRWOQQKDQRC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H23N3O3/c26-19(14-23-15-20(27)25-10-12-28-13-11-25)21-17-8-4-5-9-18(17)24-22(21)16-6-2-1-3-7-16/h1-9,23-24H,10-15H2
PubChem CID	122195452
ChEMBL	CHEMBL3633662
IUPHAR	N/A
BindingDB	50133684
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	256000.0 nM	PMID26516782	BindingDB,ChEMBL
IC50	257040.0 nM	PMID26516782	ChEMBL
IC50	257040.0 nM	PMID26516782	BindingDB
Inhibition	9.0 %	PMID26516782	ChEMBL

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