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GPCR

NameMetabotropic glutamate receptor 7
SpeciesHomo sapiens (Human)
GeneGRM7
SynonymGLUR7
glutamate receptor
GPRC1G
mGlu7 receptor
mGlu7a receptor
[ Show all ]
DiseaseN/A
Length915
Amino acid sequenceMVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProtQ14831
Protein Data Bank5c5c, 3mq4
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 5c5c.
BioLiPBL0319784,BL0319785,BL0319786,, BL0181059, BL0181060, BL0319782,BL0319783
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3777
IUPHAR295
DrugBankBE0000834

Ligand

NameCHEMBL3628112
Molecular formulaC20H12Cl2N2O4
IUPAC nameN-[3-chloro-4-(5-chloro-1,3-dioxoisoindol-2-yl)phenyl]-3-methylfuran-2-carboxamide
Molecular weight415.226
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.3
SynonymsBDBM50127965
Inchi KeyDCYOTMCWHBEKAQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H12Cl2N2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(22)9-12)24-19(26)13-4-2-11(21)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)
PubChem CID122193176
ChEMBLCHEMBL3628112
IUPHARN/A
BindingDB50127965
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
FC2.0 -PMID26426481ChEMBL

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