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GPCR

NameProbable G-protein coupled receptor 174
SpeciesHomo sapiens (Human)
GeneGPR174
SynonymFKSG79
GPR174
DiseaseN/A
Length333
Amino acid sequenceMPANYTCTRPDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFHDCKQKYDLYISIAGWLIICLACVLFPLLRTSDDTSGNRTKCFVDLPTRNVNLAQSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLQDKYPMAQDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFSTNEFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELC
UniProtQ9BXC1
Protein Data BankN/A
GPCR-HGmod modelQ9BXC1
3D structure modelThis predicted structure model is from GPCR-EXP Q9BXC1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562167
IUPHAR145
DrugBankN/A

Ligand

NameCHEMBL3577180
Molecular formulaC26H44NO9P
IUPAC name(2S)-2-amino-3-[hydroxy-[3-[3-(3-undecoxyphenyl)propanoyloxy]propoxy]phosphoryl]oxypropanoic acid
Molecular weight545.61
Hydrogen bond acceptor10
Hydrogen bond donor3
XlogP2.5
SynonymsBDBM50096478
Inchi KeyFDJQCIZKQRKPLN-DEOSSOPVSA-N
Inchi IDInChI=1S/C26H44NO9P/c1-2-3-4-5-6-7-8-9-10-17-33-23-14-11-13-22(20-23)15-16-25(28)34-18-12-19-35-37(31,32)36-21-24(27)26(29)30/h11,13-14,20,24H,2-10,12,15-19,21,27H2,1H3,(H,29,30)(H,31,32)/t24-/m0/s1
PubChem CID122177526
ChEMBLCHEMBL3577180
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50<1000.0 nMPMID25970039ChEMBL

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