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Name | Metabotropic glutamate receptor 5 |
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Species | Rattus norvegicus (Rat) |
Gene | Grm5 |
Synonym | glutamate receptor GPRC1E mGlu5 receptor mGluR5 |
Disease | N/A for non-human GPCRs |
Length | 1203 |
Amino acid sequence | MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTENRGPGAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEESFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAATPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQGATGVSPAQETPTGAESAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL |
UniProt | P31424 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2564 |
IUPHAR | 293 |
DrugBank | N/A |
Name | CHEMBL3617513 |
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Molecular formula | C21H17F4N3O3 |
IUPAC name | (7R)-5-(4-fluorophenyl)-7-methyl-2-[[4-(trifluoromethoxy)phenoxy]methyl]-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one |
Molecular weight | 435.379 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 0 |
XlogP | 4.5 |
Synonyms | BDBM50122314 |
Inchi Key | FKOGCKIUUREBFE-CYBMUJFWSA-N |
Inchi ID | InChI=1S/C21H17F4N3O3/c1-13-11-27(16-4-2-14(22)3-5-16)20(29)19-10-15(26-28(13)19)12-30-17-6-8-18(9-7-17)31-21(23,24)25/h2-10,13H,11-12H2,1H3/t13-/m1/s1 |
PubChem CID | 122190329 |
ChEMBL | CHEMBL3617513 |
IUPHAR | N/A |
BindingDB | 50122314 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <30000.0 nM | PMID26335039 | BindingDB,ChEMBL |
EC50 | <31622.8 nM | PMID26335039 | ChEMBL |
EC50 | >31623.0 nM | PMID26335039 | BindingDB |
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