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GPCR

NameProbable G-protein coupled receptor 34
SpeciesHomo sapiens (Human)
GeneGPR34
SynonymGPR34
DiseaseN/A
Length381
Amino acid sequenceMRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST
UniProtQ9UPC5
Protein Data BankN/A
GPCR-HGmod modelQ9UPC5
3D structure modelThis predicted structure model is from GPCR-EXP Q9UPC5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562165
IUPHAR101
DrugBankN/A

Ligand

NameCHEMBL3577177
Molecular formulaC22H36NO9P
IUPAC name(2S)-2-amino-3-[3-[3-(2-heptoxyphenyl)propanoyloxy]propoxy-hydroxyphosphoryl]oxypropanoic acid
Molecular weight489.502
Hydrogen bond acceptor10
Hydrogen bond donor3
XlogP0.4
SynonymsBDBM50096444
Inchi KeyFMJWNEQNALGMKR-IBGZPJMESA-N
Inchi IDInChI=1S/C22H36NO9P/c1-2-3-4-5-8-14-29-20-11-7-6-10-18(20)12-13-21(24)30-15-9-16-31-33(27,28)32-17-19(23)22(25)26/h6-7,10-11,19H,2-5,8-9,12-17,23H2,1H3,(H,25,26)(H,27,28)/t19-/m0/s1
PubChem CID122177523
ChEMBLCHEMBL3577177
IUPHARN/A
BindingDB50096444
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<1000.0 nMPMID25970039BindingDB,ChEMBL

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