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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Mus musculus (Mouse)
Gene	Gpr119
Synonym	G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 GPR119 [ Show all ]
Disease	N/A for non-human GPCRs
Length	335
Amino acid sequence	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProt	Q7TQP3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5263
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3622174
Molecular formula	C23H30FN3O3S
IUPAC name	5-ethyl-2-[4-[(1R,2R)-2-[(3-fluoro-4-methylsulfonylphenyl)methoxymethyl]cyclopropyl]piperidin-1-yl]pyrimidine
Molecular weight	447.569
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.5
Synonyms	SCHEMBL14325503
Inchi Key	HLLLFECGPUXECV-VQTJNVASSA-N
Inchi ID	InChI=1S/C23H30FN3O3S/c1-3-16-12-25-23(26-13-16)27-8-6-18(7-9-27)20-11-19(20)15-30-14-17-4-5-22(21(24)10-17)31(2,28)29/h4-5,10,12-13,18-20H,3,6-9,11,14-15H2,1-2H3/t19-,20+/m0/s1
PubChem CID	71140721
ChEMBL	CHEMBL3622174
IUPHAR	N/A
BindingDB	50122846
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	115.0 %	PMID26288697	ChEMBL
EC50	5.5 nM	PMID26288697	BindingDB,ChEMBL

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