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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	C-X-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CXCR3
Synonym	MigR IP-10 receptor Interferon-inducible protein 10 receptor GPR9 G protein-coupled receptor 9 Cxcr3 CXCR-3 CXC-R3 CKR-L2 chemokine (C-X-C motif) receptor 3 CD183 [ Show all ]
Disease	Inflammatory disease Autoimmune diabetes Inflammatory disorder Rheumatoid arthritis Psoriatic disorder
Length	368
Amino acid sequence	MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
UniProt	P49682
Protein Data Bank	N/A
GPCR-HGmod model	P49682
3D structure model	This predicted structure model is from GPCR-EXP P49682.
BioLiP	N/A
Therapeutic Target Database	T25315
ChEMBL	CHEMBL4441
IUPHAR	70
DrugBank	N/A

Ligand

Name	CHEMBL372529
Molecular formula	C30H31Cl2F2N5O3
IUPAC name	4-[4-[2-(2,4-dichlorophenyl)ethylcarbamoyl]-2-[(3,4-difluorobenzoyl)amino]phenyl]-N-ethyl-1,4-diazepane-1-carboxamide
Molecular weight	618.507
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	5.4
Synonyms	BDBM50175182 SCHEMBL4589103 4-(4-((2,4-dichlorophenethyl)carbamoyl)-2-(3,4-difluorobenzamido)phenyl)-N-ethyl-1,4-diazepane-1-carboxamide
Inchi Key	AGDLGOIDLZWXJE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H31Cl2F2N5O3/c1-2-35-30(42)39-13-3-12-38(14-15-39)27-9-6-21(28(40)36-11-10-19-4-7-22(31)18-23(19)32)17-26(27)37-29(41)20-5-8-24(33)25(34)16-20/h4-9,16-18H,2-3,10-15H2,1H3,(H,35,42)(H,36,40)(H,37,41)
PubChem CID	15605137
ChEMBL	CHEMBL372529
IUPHAR	N/A
BindingDB	50175182
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	290.0 nM	PMID16213722	BindingDB,ChEMBL

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