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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Corticotropin-releasing factor receptor 2
Species	Homo sapiens (Human)
Gene	CRHR2
Synonym	CRH-R2 CRH-R-2 CRFR2beta CRFR2alpha CRFR2 CRFR-2 CRF2 receptor CRF-R2 CRF-R-2 CRF 2 receptor Corticotropin-releasing hormone receptor 2 [ Show all ]
Disease	Generalized anxiety disorder Anxiety disorder Congestive heart failure Eating disorders stimulate food consumption anxiety
Length	411
Amino acid sequence	MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
UniProt	Q13324
Protein Data Bank	N/A
GPCR-HGmod model	Q13324
3D structure model	This predicted structure model is from GPCR-EXP Q13324.
BioLiP	N/A
Therapeutic Target Database	T11011
ChEMBL	CHEMBL4069
IUPHAR	213
DrugBank	N/A

Ligand

Name	CHEMBL3628734
Molecular formula	C24H33BrN4O
IUPAC name	4-(2-bromo-4-tert-butylphenyl)-8-[butyl(ethyl)amino]-6-methyl-1,3-dihydropyrido[2,3-b]pyrazin-2-one
Molecular weight	473.459
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	6.4
Synonyms	BDBM50128778
Inchi Key	MJSWCHNBFDPOGD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H33BrN4O/c1-7-9-12-28(8-2)20-13-16(3)26-23-22(20)27-21(30)15-29(23)19-11-10-17(14-18(19)25)24(4,5)6/h10-11,13-14H,7-9,12,15H2,1-6H3,(H,27,30)
PubChem CID	122193717
ChEMBL	CHEMBL3628734
IUPHAR	N/A
BindingDB	50128778
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	-3.8 %	PMID26456805	ChEMBL

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