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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	CHEMBL3590074
Molecular formula	C31H35N5O3
IUPAC name	(2R)-3-(1H-indol-3-yl)-2-[(4-methoxyphenyl)carbamoylamino]-N-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide
Molecular weight	525.653
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	5.2
Synonyms	(2R)-N-[1-(2-Pyridyl)cyclohexylmethyl]-3-(1H-indole-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamide BDBM50097570
Inchi Key	NTFUQLNNSFGESC-HHHXNRCGSA-N
Inchi ID	InChI=1S/C31H35N5O3/c1-39-24-14-12-23(13-15-24)35-30(38)36-27(19-22-20-33-26-10-4-3-9-25(22)26)29(37)34-21-31(16-6-2-7-17-31)28-11-5-8-18-32-28/h3-5,8-15,18,20,27,33H,2,6-7,16-17,19,21H2,1H3,(H,34,37)(H2,35,36,38)/t27-/m1/s1
PubChem CID	122181323
ChEMBL	CHEMBL3590074
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	310.0 nM	PMID25549897	ChEMBL
EC50	490.0 nM	PMID25549897	ChEMBL
EC50	620.0 nM	PMID25549897	ChEMBL
Efficacy	40.0 %	PMID25549897	ChEMBL
Efficacy	90.0 %	PMID25549897	ChEMBL
Efficacy	115.0 %	PMID25549897	ChEMBL

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