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Name | Mu-type opioid receptor |
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Species | Homo sapiens (Human) |
Gene | OPRM1 |
Synonym | hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor [ Show all ] |
Disease | Diarrhea Inflammatory disease Pain Major depressive disorder Migraine [ Show all ] |
Length | 400 |
Amino acid sequence | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP |
UniProt | P35372 |
Protein Data Bank | N/A |
GPCR-HGmod model | P35372 |
3D structure model | This predicted structure model is from GPCR-EXP P35372. |
BioLiP | N/A |
Therapeutic Target Database | T47768 |
ChEMBL | CHEMBL233 |
IUPHAR | 319 |
DrugBank | BE0000770 |
Name | U-69593 |
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Molecular formula | C22H32N2O2 |
IUPAC name | N-methyl-2-phenyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide |
Molecular weight | 356.51 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 3.0 |
Synonyms | (5alpha,7alpha,8beta)-(-)-N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-benzeneacetamide AOB5676 benzeneacetamide, N-methyl-N-[(5R,7S,8S)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]- D0V3OY KB-62197 [ Show all ] |
Inchi Key | PGZRDDYTKFZSFR-ONTIZHBOSA-N |
Inchi ID | InChI=1S/C22H32N2O2/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24/h2-4,8-9,19-20H,5-7,10-17H2,1H3/t19-,20-,22-/m0/s1 |
PubChem CID | 105104 |
ChEMBL | CHEMBL440765 |
IUPHAR | 1656, 1655 |
BindingDB | 21130 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <10000.0 nM | PMID12672258 | ChEMBL |
IC50 | 248.0 nM | PMID11755353 | BindingDB,ChEMBL |
IC50 | 250.0 nM | PMID12643930 | BindingDB,ChEMBL |
Ki | <1000.0 nM | PMID12930147 | ChEMBL |
Ki | <2000.0 nM | PMID23618710, PMID25599950 | ChEMBL |
Ki | <10000.0 nM | PMID21866885 | ChEMBL |
Ki | 1000.0 nM | PMID8114680 | BindingDB |
Ki | 1145.0 nM | PMID23134120, PMID12672258, PMID9686407 | BindingDB,ChEMBL |
Ki | 2370.0 nM | PMID22341895, PMID23880358 | ChEMBL |
Stimulation | <10000.0 % | PMID12672258 | ChEMBL |
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