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GPCR

NameProbable G-protein coupled receptor 34
SpeciesHomo sapiens (Human)
GeneGPR34
SynonymGPR34
DiseaseN/A
Length381
Amino acid sequenceMRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST
UniProtQ9UPC5
Protein Data BankN/A
GPCR-HGmod modelQ9UPC5
3D structure modelThis predicted structure model is from GPCR-EXP Q9UPC5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562165
IUPHAR101
DrugBankN/A

Ligand

NameCHEMBL3577151
Molecular formulaC20H40NO8P
IUPAC name(2S)-2-amino-3-[hydroxy(3-tetradecanoyloxypropoxy)phosphoryl]oxypropanoic acid
Molecular weight453.513
Hydrogen bond acceptor9
Hydrogen bond donor3
XlogP1.9
SynonymsBDBM50096357
Inchi KeyPQVATKARQXQHPW-SFHVURJKSA-N
Inchi IDInChI=1S/C20H40NO8P/c1-2-3-4-5-6-7-8-9-10-11-12-14-19(22)27-15-13-16-28-30(25,26)29-17-18(21)20(23)24/h18H,2-17,21H2,1H3,(H,23,24)(H,25,26)/t18-/m0/s1
PubChem CID122177499
ChEMBLCHEMBL3577151
IUPHARN/A
BindingDB50096357
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50700.0 nMPMID25970039BindingDB,ChEMBL
EC50707.95 nMPMID25970039ChEMBL
EC50708.0 nMPMID25970039BindingDB

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