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GPCR

NameD(1A) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD1
SynonymDopamine-1A receptor
DADR
D1 receptor
dopamine D1 receptor
Gpcr15
[ Show all ]
DiseaseType 2 diabetes
Unspecified
Substance dependence
Schizophrenia
Psychotic disorders
[ Show all ]
Length446
Amino acid sequenceMRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProtP21728
Protein Data BankN/A
GPCR-HGmod modelP21728
3D structure modelThis predicted structure model is from GPCR-EXP P21728.
BioLiPN/A
Therapeutic Target DatabaseT22118
ChEMBLCHEMBL2056
IUPHAR214
DrugBankBE0000020

Ligand

Name7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
Molecular formulaC22H40O2
IUPAC name(5Z,8Z)-7,7-dimethylicosa-5,8-dienoic acid
Molecular weight336.56
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP8.5
SynonymsDEDA
AGKRHAILCPYNFH-DUQSFWPASA-N
7,7-dimethyleicosadienoic acid
89560-01-0
7,7-dimethyl-5Z,8Z-eicosadienoic acid
[ Show all ]
Inchi KeyAGKRHAILCPYNFH-DUQSFWPASA-N
Inchi IDInChI=1S/C22H40O2/c1-4-5-6-7-8-9-10-11-12-13-16-19-22(2,3)20-17-14-15-18-21(23)24/h16-17,19-20H,4-15,18H2,1-3H3,(H,23,24)/b19-16-,20-17-
PubChem CID5312331
ChEMBLCHEMBL1323529
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Potency2909.1 nMPubChem BioAssay data setChEMBL

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