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GPCR

NameProbable G-protein coupled receptor 34
SpeciesHomo sapiens (Human)
GeneGPR34
SynonymGPR34
DiseaseN/A
Length381
Amino acid sequenceMRSHTITMTTTSVSSWPYSSHRMRFITNHSDQPPQNFSATPNVTTCPMDEKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRKAITTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYRDKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKTNEIMLVLSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQGEPSRSESTSEFKPGYSLHDTSVAVKIQSSSKST
UniProtQ9UPC5
Protein Data BankN/A
GPCR-HGmod modelQ9UPC5
3D structure modelThis predicted structure model is from GPCR-EXP Q9UPC5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562165
IUPHAR101
DrugBankN/A

Ligand

NameCHEMBL3577182
Molecular formulaC26H43FNO9P
IUPAC name(2S)-2-amino-3-[[(2R)-2-fluoro-3-[3-(2-undecoxyphenyl)propanoyloxy]propoxy]-hydroxyphosphoryl]oxypropanoic acid
Molecular weight563.6
Hydrogen bond acceptor11
Hydrogen bond donor3
XlogP2.6
SynonymsBDBM50096400
Inchi KeyRJDYAPVWZJLYAA-PKTZIBPZSA-N
Inchi IDInChI=1S/C26H43FNO9P/c1-2-3-4-5-6-7-8-9-12-17-34-24-14-11-10-13-21(24)15-16-25(29)35-18-22(27)19-36-38(32,33)37-20-23(28)26(30)31/h10-11,13-14,22-23H,2-9,12,15-20,28H2,1H3,(H,30,31)(H,32,33)/t22-,23+/m1/s1
PubChem CID122177528
ChEMBLCHEMBL3577182
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50933.25 nMPMID25970039ChEMBL
EC50940.0 nMPMID25970039ChEMBL

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