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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Free fatty acid receptor 2
Species	Homo sapiens (Human)
Gene	FFAR2
Synonym	FFA2R G protein-coupled receptor 43 G-protein coupled receptor 43 GPCR3 GPR43 FFA2 receptor [ Show all ]
Disease	Abortion Diabetes
Length	330
Amino acid sequence	MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProt	O15552
Protein Data Bank	N/A
GPCR-HGmod model	O15552
3D structure model	This predicted structure model is from GPCR-EXP O15552.
BioLiP	N/A
Therapeutic Target Database	T28213
ChEMBL	CHEMBL5493
IUPHAR	226
DrugBank	N/A

Ligand

Name	CHEMBL594974
Molecular formula	C15H14ClFN2OS
IUPAC name	1-(4-chlorophenyl)-N-(5-fluoro-1,3-thiazol-2-yl)cyclopentane-1-carboxamide
Molecular weight	324.798
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.5
Synonyms	1-(4-chlorophenyl)-N-(5-fluorothiazol-2-yl)cyclopentanecarboxamide BDBM50305931
Inchi Key	CTGZTILKRROOMM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H14ClFN2OS/c16-11-5-3-10(4-6-11)15(7-1-2-8-15)13(20)19-14-18-9-12(17)21-14/h3-6,9H,1-2,7-8H2,(H,18,19,20)
PubChem CID	46226361
ChEMBL	CHEMBL594974
IUPHAR	N/A
BindingDB	50305931
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Efficacy	88.0 %	PMID20005104	ChEMBL
IC50	5000.0 nM	PMID20005104	BindingDB,ChEMBL

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