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GPCR

NameGalanin receptor type 2
SpeciesHomo sapiens (Human)
GeneGALR2
SynonymGAL2 receptor
GAL2-R
GALNR2
GALR-2
DiseaseN/A
Length387
Amino acid sequenceMNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProtO43603
Protein Data BankN/A
GPCR-HGmod modelO43603
3D structure modelThis predicted structure model is from GPCR-EXP O43603.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3176
IUPHAR244
DrugBankN/A

Ligand

Nameellipticine
Molecular formulaC17H14N2
IUPAC name5,11-dimethyl-6H-pyrido[4,3-b]carbazole
Molecular weight246.313
Hydrogen bond acceptor1
Hydrogen bond donor1
XlogP4.8
Synonyms117VLW7484
33668-12-1 (hydrochloride)
5,11- paragraph signthorn(1/4)x>>u-6H-ssAa currency(2) cent[4,3-b]ssCsso
5,11-dimethyl-2H-pyrido[4,3-b]carbazole
5,11-Dimethyl-6H-pyrido(4,3-b)carbazole
[ Show all ]
Inchi KeyCTSPAMFJBXKSOY-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3
PubChem CID3213
ChEMBLCHEMBL123
IUPHARN/A
BindingDB50004233
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<55700.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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