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GPCR

NameD(1A) dopamine receptor
SpeciesSus scrofa (Pig)
GeneDRD1
SynonymDopamine D1 receptor
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMRTLNTSTMDGTGLVVERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNVTSLGKTTHNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPAECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTSTNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIASPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProtP50130
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5067
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1928124
Molecular formulaC27H39N3O4
IUPAC name4-(2-ethoxyethoxymethyl)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]benzamide
Molecular weight469.626
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP3.4
SynonymsBDBM50359765
Inchi KeyCTWFQXKVAMVTEI-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H39N3O4/c1-3-33-20-21-34-22-23-10-12-24(13-11-23)27(31)28-14-6-7-15-29-16-18-30(19-17-29)25-8-4-5-9-26(25)32-2/h4-5,8-13H,3,6-7,14-22H2,1-2H3,(H,28,31)
PubChem CID57395340
ChEMBLCHEMBL1928124
IUPHARN/A
BindingDB50359765
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki3600.0 nMPMID22100258BindingDB,ChEMBL

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