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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor-like 2
Species	Homo sapiens (Human)
Gene	CCRL2
Synonym	ACR5 CRAM-B CRAM-A CKRX Chemokine receptor X Chemokine receptor CCR11 CCRL2 CCR6 CCR11 Putative MCP-1 chemokine receptor [ Show all ]
Disease	N/A
Length	344
Amino acid sequence	MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
UniProt	O00421
Protein Data Bank	N/A
GPCR-HGmod model	O00421
3D structure model	This predicted structure model is from GPCR-EXP O00421.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2321627
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL9999220
Molecular formula	C24H32F3N5O2
IUPAC name	N-[1-[4-(1-hydroxy-2-methylpropyl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide
Molecular weight	479.548
Hydrogen bond acceptor	9
Hydrogen bond donor	3
XlogP	4.2
Synonyms	US9062048, (-) 8 SCHEMBL12052924 BDBM163262 SCHEMBL9999221 CHEMBL3659056 US9062048, 7 SCHEMBL12072078 BDBM163606 US9062048, (+) 8 CHEMBL3704027 [ Show all ]
Inchi Key	VDQZYRCKECVTGJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H32F3N5O2/c1-14(2)22(34)15-3-6-18(7-4-15)32-11-17(12-32)31-21(33)10-28-23-19-9-16(24(25,26)27)5-8-20(19)29-13-30-23/h5,8-9,13-15,17-18,22,34H,3-4,6-7,10-12H2,1-2H3,(H,31,33)(H,28,29,30)
PubChem CID	54769954
ChEMBL	CHEMBL3659056
IUPHAR	N/A
BindingDB	163606
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	10.0 nM	, None	BindingDB,ChEMBL
IC50	44.0 nM	, None	BindingDB,ChEMBL

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