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GPCR

NameAlpha-2A adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra2a
Synonymalpha2A-adrenergic receptor
Alpha-2A adrenoceptor
Adrenergic alpha 2A receptor
Alpha-2A adrenoreceptor
CA2-47
[ Show all ]
DiseaseN/A for non-human GPCRs
Length450
Amino acid sequenceMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProtP22909
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL327
IUPHARN/A
DrugBankN/A

Ligand

NameDEXMEDETOMIDINE
Molecular formulaC13H16N2
IUPAC name5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
Molecular weight200.285
Hydrogen bond acceptor1
Hydrogen bond donor1
XlogP3.1
Synonyms113775-47-6
Dexmedetomidina
Dexmedetomidinum
MPV 1440
UNII-67VB76HONO
[ Show all ]
Inchi KeyCUHVIMMYOGQXCV-NSHDSACASA-N
Inchi IDInChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1
PubChem CID5311068
ChEMBLCHEMBL778
IUPHAR521
BindingDB50085683
DrugBankDB00633

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.015 nMPMID10715142BindingDB
Ki0.015 nMPMID10715142, PMID10753480BindingDB,ChEMBL
Ki5.0 nMPMID10753480BindingDB,ChEMBL

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