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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesHomo sapiens (Human)
GeneHTR4
Synonym5-HT-4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
5-HT4 receptor
5-HT4
serotonin receptor 4
DiseaseN/A
Length388
Amino acid sequenceMDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProtQ13639
Protein Data BankN/A
GPCR-HGmod modelQ13639
3D structure modelThis predicted structure model is from GPCR-EXP Q13639.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1875
IUPHAR9
DrugBankBE0000084

Ligand

NameCHEMBL82360
Molecular formulaC17H25ClN2O2
IUPAC name1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-ethylpiperidin-4-yl)propan-1-one
Molecular weight324.849
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.0
SynonymsBDBM50213015
SCHEMBL7354794
Inchi KeyAATBBQHADVZFQY-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H25ClN2O2/c1-3-20-8-6-12(7-9-20)4-5-16(21)13-10-14(18)15(19)11-17(13)22-2/h10-12H,3-9,19H2,1-2H3
PubChem CID19081860
ChEMBLCHEMBL82360
IUPHARN/A
BindingDB50213015
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5015.85 nMBioorg. Med. Chem. Lett., (1994) 4:20:2477ChEMBL
EC5016.0 nMN/ABindingDB
Intrinsic activity0.61 -Bioorg. Med. Chem. Lett., (1994) 4:20:2477ChEMBL

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