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GPCR

NameNeuropeptide Y receptor type 2
SpeciesHomo sapiens (Human)
GeneNPY2R
SynonymNPY2-R
NPY-Y2 receptor
neuropeptide Y receptor type 2
Y2 receptor
DiseaseDiabetes
Metabolic disorders
Obesity
Length381
Amino acid sequenceMGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProtP49146
Protein Data BankN/A
GPCR-HGmod modelP49146
3D structure modelThis predicted structure model is from GPCR-EXP P49146.
BioLiPN/A
Therapeutic Target DatabaseT10670
ChEMBLCHEMBL4018
IUPHAR306
DrugBankBE0002419

Ligand

NameCHEMBL1823343
Molecular formulaC31H30N4O3
IUPAC namemethyl 2-phenyl-2-[4-[4-[(2-pyridin-4-ylbenzoyl)amino]phenyl]piperazin-1-yl]acetate
Molecular weight506.606
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.9
SynonymsBDBM50352372
SCHEMBL12174433
Inchi KeyAGRKYGCNRKSAJV-UHFFFAOYSA-N
Inchi IDInChI=1S/C31H30N4O3/c1-38-31(37)29(24-7-3-2-4-8-24)35-21-19-34(20-22-35)26-13-11-25(12-14-26)33-30(36)28-10-6-5-9-27(28)23-15-17-32-18-16-23/h2-18,29H,19-22H2,1H3,(H,33,36)
PubChem CID20773958
ChEMBLCHEMBL1823343
IUPHARN/A
BindingDB50352372
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC50240.0 nMPMID21802951BindingDB,ChEMBL

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