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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 2
Species	Homo sapiens (Human)
Gene	F2RL1
Synonym	Protease-activated receptor-2 PAR2 PAR-2 GPR11 G-protein coupled receptor 11 coagulation factor II receptor-like 1 coagulation factor II (thrombin) receptor-like 1 Thrombin receptor-like 1 [ Show all ]
Disease	N/A
Length	397
Amino acid sequence	MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
UniProt	P55085
Protein Data Bank	5ndz, 5ndd
GPCR-HGmod model	P55085
3D structure model	This structure is from PDB ID 5ndz.
BioLiP	BL0377325, BL0377326
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5963
IUPHAR	348
DrugBank	N/A

Ligand

Name	CHEMBL1271236
Molecular formula	C20H32N4O4
IUPAC name	N-[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-2-methyl-1,3-oxazole-4-carboxamide
Molecular weight	392.5
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	3.5
Synonyms	BDBM50329486 4-(2-Methyloxazoyl)-Cha-Ile-NH2
Inchi Key	CVJTZEAKXFGAEL-NUTKFTJISA-N
Inchi ID	InChI=1S/C20H32N4O4/c1-4-12(2)17(18(21)25)24-19(26)15(10-14-8-6-5-7-9-14)23-20(27)16-11-28-13(3)22-16/h11-12,14-15,17H,4-10H2,1-3H3,(H2,21,25)(H,23,27)(H,24,26)/t12-,15-,17-/m0/s1
PubChem CID	49788155
ChEMBL	CHEMBL1271236
IUPHAR	N/A
BindingDB	50329486
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	PMID20873792	BindingDB,ChEMBL

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