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GLASS

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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	CHEMBL3560415
Molecular formula	C22H25BrN2O3
IUPAC name	(E)-3-(4-bromophenyl)-1-[4-[(3,5-dimethoxyphenyl)methyl]piperazin-1-yl]prop-2-en-1-one
Molecular weight	445.357
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.7
Synonyms	SCHEMBL16599349 MLS-0472533.0001 SCHEMBL16599348
Inchi Key	ZHYUXPHZQKDUCG-VMPITWQZSA-N
Inchi ID	InChI=1S/C22H25BrN2O3/c1-27-20-13-18(14-21(15-20)28-2)16-24-9-11-25(12-10-24)22(26)8-5-17-3-6-19(23)7-4-17/h3-8,13-15H,9-12,16H2,1-2H3/b8-5+
PubChem CID	73330404
ChEMBL	CHEMBL3560415
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3.64 nM	PubChem BioAssay data set	ChEMBL

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