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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 174
Species	Homo sapiens (Human)
Gene	GPR174
Synonym	FKSG79 GPR174
Disease	N/A
Length	333
Amino acid sequence	MPANYTCTRPDGDNTDFRYFIYAVTYTVILVPGLIGNILALWVFYGYMKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNHDWPFGPGLCMFCFYLKYVNMYASIYFLVCISVRRFWFLMYPFRFHDCKQKYDLYISIAGWLIICLACVLFPLLRTSDDTSGNRTKCFVDLPTRNVNLAQSVVMMTIGELIGFVTPLLIVLYCTWKTVLSLQDKYPMAQDLGEKQKALKMILTCAGVFLICFAPYHFSFPLDFLVKSNEIKSCLARRVILIFHSVALCLASLNSCLDPVIYYFSTNEFRRRLSRQDLHDSIQLHAKSFVSNHTASTMTPELC
UniProt	Q9BXC1
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXC1
3D structure model	This predicted structure model is from GPCR-EXP Q9BXC1.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3562167
IUPHAR	145
DrugBank	N/A

Ligand

Name	CHEMBL3577146
Molecular formula	C20H40NO9P
IUPAC name	(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-tetradecanoyloxypropoxy]phosphoryl]oxypropanoic acid
Molecular weight	469.512
Hydrogen bond acceptor	10
Hydrogen bond donor	4
XlogP	0.9
Synonyms	LPS(14:0) PS(14:0/0:0) LPS(14:0/0:0) BDBM50096425 LMGP03050009 1-tetradecanoyl-glycero-3-phosphoserine Myristoyllysophosphatidylserine [ Show all ]
Inchi Key	ZJMQYSXCPARLHG-MSOLQXFVSA-N
Inchi ID	InChI=1S/C20H40NO9P/c1-2-3-4-5-6-7-8-9-10-11-12-13-19(23)28-14-17(22)15-29-31(26,27)30-16-18(21)20(24)25/h17-18,22H,2-16,21H2,1H3,(H,24,25)(H,26,27)/t17-,18+/m1/s1
PubChem CID	52926277
ChEMBL	CHEMBL3577146
IUPHAR	N/A
BindingDB	50096425
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	770.0 nM	PMID25970039	BindingDB,ChEMBL
EC50	776.0 nM	PMID25970039	BindingDB
EC50	776.25 nM	PMID25970039	ChEMBL

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