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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameBDBM50098567
Molecular formulaC125H184N32O33S
IUPAC name(3S)-4-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-3-hydroxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-(6-phenylhexanoylamino)propanoyl]amino]propanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-oxobutanoic acid
Molecular weight2695.1
Hydrogen bond acceptor37
Hydrogen bond donor39
XlogP-5.0
Synonymsphenylhexanoyl-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2
Inchi KeyCVVMIBPWQAJFQU-XEWGCOIWSA-N
Inchi IDInChI=1S/C125H184N32O33S/c1-65(2)53-85(112(179)144-84(48-52-191-9)111(178)151-91(59-98(129)165)120(187)157-103(69(8)160)104(130)171)147-116(183)90(58-74-62-137-78-31-20-19-30-77(74)78)150-110(177)83(45-47-97(128)164)145-123(190)102(67(5)6)156-119(186)89(55-71-28-16-11-17-29-71)149-117(184)92(60-100(167)168)152-109(176)82(44-46-96(127)163)140-105(172)68(7)138-106(173)80(33-23-50-135-124(131)132)141-107(174)81(34-24-51-136-125(133)134)143-122(189)95(64-159)155-118(185)93(61-101(169)170)153-113(180)86(54-66(3)4)146-115(182)88(57-73-38-42-76(162)43-39-73)148-108(175)79(32-21-22-49-126)142-121(188)94(63-158)154-114(181)87(56-72-36-40-75(161)41-37-72)139-99(166)35-18-12-15-27-70-25-13-10-14-26-70/h10-11,13-14,16-17,19-20,25-26,28-31,36-43,62,65-69,79-95,102-103,137,158-162H,12,15,18,21-24,27,32-35,44-61,63-64,126H2,1-9H3,(H2,127,163)(H2,128,164)(H2,129,165)(H2,130,171)(H,138,173)(H,139,166)(H,140,172)(H,141,174)(H,142,188)(H,143,189)(H,144,179)(H,145,190)(H,146,182)(H,147,183)(H,148,175)(H,149,184)(H,150,177)(H,151,178)(H,152,176)(H,153,180)(H,154,181)(H,155,185)(H,156,186)(H,157,187)(H,167,168)(H,169,170)(H4,131,132,135)(H4,133,134,136)/t68-,69+,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,102-,103-/m0/s1
PubChem CID91931634
ChEMBLCHEMBL439690
IUPHARN/A
BindingDB50098567
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC50131.0 nMPMID11311060BindingDB,ChEMBL
Relative binding1.1 %PMID11311060ChEMBL

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