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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	CHEMBL156742
Molecular formula	C18H17N3O4
IUPAC name	ethyl 3-benzyl-1-methyl-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxylate
Molecular weight	339.351
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	1.8
Synonyms	SCHEMBL6514548 BDBM50219192 1-Methyl-2,4-dioxo-3-benzyl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
Inchi Key	JUOBVXRRAOMWEM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H17N3O4/c1-3-25-17(23)13-9-14-15(19-10-13)20(2)18(24)21(16(14)22)11-12-7-5-4-6-8-12/h4-10H,3,11H2,1-2H3
PubChem CID	44370855
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50097570
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	310.0 nM	PMID25549897	BindingDB
EC50	490.0 nM	PMID25549897	BindingDB
EC50	620.0 nM	PMID25549897	BindingDB

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