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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 8
Species	Homo sapiens (Human)
Gene	TAS2R8
Synonym	T2R8 TAS2R8 Taste receptor family B member 5 taste receptor, type 2, member 8 TRB5
Disease	N/A
Length	309
Amino acid sequence	MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProt	Q9NYW2
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYW2
3D structure model	This predicted structure model is from GPCR-EXP Q9NYW2.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3988599
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279016
Molecular formula	C20H20FN5O3
IUPAC name	3-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-1-[2-(4-fluorophenyl)ethyl]imidazolidine-2,4-dione
Molecular weight	397.41
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	2.1
Synonyms	AUROVVWMYRRKTO-UHFFFAOYSA-N CHEMBL3976506 3-(1((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(4-fluorophenethyl)imidazolidine-2,4-dione BDBM211336 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(4-fluorophenethyl)imidazolidine-2,4-dione US9247759, 10-84 [ Show all ]
Inchi Key	AUROVVWMYRRKTO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H20FN5O3/c1-13-18(14(2)29-23-13)11-25-10-17(9-22-25)26-19(27)12-24(20(26)28)8-7-15-3-5-16(21)6-4-15/h3-6,9-10H,7-8,11-12H2,1-2H3
PubChem CID	57944929
ChEMBL	CHEMBL3976506
IUPHAR	N/A
BindingDB	211336
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	10.0 nM	None	ChEMBL
IC50	10.0 nM	N/A	BindingDB

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