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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL124312
Molecular formulaC30H62NO3+
IUPAC name6-[(2-heptadecyl-1,3-dioxolan-4-yl)methoxy]hexyl-trimethylazanium
Molecular weight484.83
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP10.1
SynonymsBDBM50011094
Toluene-4-sulfonate[6-(2-heptadecyl-[1,3]dioxolan-4-ylmethoxy)-hexyl]-trimethyl-ammonium;Toluene-4-sulfonate
CHEMBL1180375
6-(2-Heptadecyl-1,3-dioxolan-4-ylmethoxy)-N,N,N-trimethylhexan-1-aminium
Inchi KeyBIGGYKUNDXTXTN-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H62NO3/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-24-30-33-28-29(34-30)27-32-26-23-20-19-22-25-31(2,3)4/h29-30H,5-28H2,1-4H3/q+1
PubChem CID14785936
ChEMBLN/A
IUPHARN/A
BindingDB50011094
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC502400.0 nMPMID1992139BindingDB

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