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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL64493
Molecular formulaC24H21N3O2S
IUPAC name(7-phenylmethoxyindol-1-yl)-[(4R)-2-pyridin-3-yl-1,3-thiazolidin-4-yl]methanone
Molecular weight415.511
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.0
SynonymsBDBM50038784
(7-Benzyloxy-indol-1-yl)-((R)-2-pyridin-3-yl-thiazolidin-4-yl)-methanone; compound with oxalic acid
CHEMBL1179198
Inchi KeyBJENIYJBEWYWPI-AJZOCDQUSA-N
Inchi IDInChI=1S/C24H21N3O2S/c28-24(20-16-30-23(26-20)19-9-5-12-25-14-19)27-13-11-18-8-4-10-21(22(18)27)29-15-17-6-2-1-3-7-17/h1-14,20,23,26H,15-16H2/t20-,23?/m0/s1
PubChem CID10476962
ChEMBLN/A
IUPHARN/A
BindingDB50038784
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki385.0 nMPMID8027984BindingDB

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