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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1615834
Molecular formulaC19H22N4O4
IUPAC name2-(3,4-dimethoxyphenyl)-N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]acetamide
Molecular weight370.409
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP1.8
SynonymsBDBM210999
US9247759, 4-34
CHEMBL3955012
Inchi KeyBJNHEAMDRAPFMJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H22N4O4/c1-12-16(13(2)27-22-12)11-23-10-15(9-20-23)21-19(24)8-14-5-6-17(25-3)18(7-14)26-4/h5-7,9-10H,8,11H2,1-4H3,(H,21,24)
PubChem CID57944941
ChEMBLCHEMBL3955012
IUPHARN/A
BindingDB210999
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501110.0 nMN/ABindingDB
IC501110.0 nMNoneChEMBL

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