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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1279043
Molecular formulaC19H20N4O5
IUPAC nameN-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-5-methoxy-2,3-dihydro-1,4-benzodioxine-7-carboxamide
Molecular weight384.392
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP1.6
SynonymsN-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-8-methoxy-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide
CHEMBL3943473
BDBM211078
GTRVUCXRYNIUCO-UHFFFAOYSA-N
US9247759, 4-93
Inchi KeyGTRVUCXRYNIUCO-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H20N4O5/c1-11-15(12(2)28-22-11)10-23-9-14(8-20-23)21-19(24)13-6-16(25-3)18-17(7-13)26-4-5-27-18/h6-9H,4-5,10H2,1-3H3,(H,21,24)
PubChem CID57422328
ChEMBLCHEMBL3943473
IUPHARN/A
BindingDB211078
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50700.0 nMN/ABindingDB
IC50700.0 nMNoneChEMBL

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