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GPCR

NameTaste receptor type 2 member 8
SpeciesHomo sapiens (Human)
GeneTAS2R8
SynonymT2R8
TAS2R8
Taste receptor family B member 5
taste receptor, type 2, member 8
TRB5
DiseaseN/A
Length309
Amino acid sequenceMFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
UniProtQ9NYW2
Protein Data BankN/A
GPCR-HGmod modelQ9NYW2
3D structure modelThis predicted structure model is from GPCR-EXP Q9NYW2.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3988599
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL1650803
Molecular formulaC18H17BrN4O4
IUPAC name6-bromo-N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-4-yl]-2,3-dihydro-1,4-benzodioxine-7-carboxamide
Molecular weight433.262
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP2.3
SynonymsCHEMBL3953071
BDBM211053
US9247759, 4-89
Inchi KeyHINOVUVRMGZYFS-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H17BrN4O4/c1-10-14(11(2)27-22-10)9-23-8-12(7-20-23)21-18(24)13-5-16-17(6-15(13)19)26-4-3-25-16/h5-8H,3-4,9H2,1-2H3,(H,21,24)
PubChem CID57944992
ChEMBLCHEMBL3953071
IUPHARN/A
BindingDB211053
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50300.0 nMN/ABindingDB
IC50300.0 nMNoneChEMBL

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