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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279102
Molecular formula	C22H19NO5S
IUPAC name	4-[(2-methoxy-5,7-dihydrobenzo[d][2]benzazepin-6-yl)sulfonyl]benzoic acid
Molecular weight	409.456
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	3.3
Synonyms	BDBM211211 US9247759, 5-158 CHEMBL3902438
Inchi Key	JCLVGASOVFXYMD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H19NO5S/c1-28-18-9-6-17-14-23(13-16-4-2-3-5-20(16)21(17)12-18)29(26,27)19-10-7-15(8-11-19)22(24)25/h2-12H,13-14H2,1H3,(H,24,25)
PubChem CID	57944905
ChEMBL	CHEMBL3902438
IUPHAR	N/A
BindingDB	211211
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3571.0 nM	None	ChEMBL
IC50	3571.0 nM	N/A	BindingDB

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