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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279106
Molecular formula	C23H23NO6S
IUPAC name	4-[benzyl-[(3,4-dimethoxyphenyl)methyl]sulfamoyl]benzoic acid
Molecular weight	441.498
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.5
Synonyms	4-(N-benzyl-N-(3,4-dimethoxybenzyl)sulfamoyl)benzoic acid CHEMBL3978302 US9247759, 5-39 BDBM211115 JYCCWYMRUFKVEH-UHFFFAOYSA-N
Inchi Key	JYCCWYMRUFKVEH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H23NO6S/c1-29-21-13-8-18(14-22(21)30-2)16-24(15-17-6-4-3-5-7-17)31(27,28)20-11-9-19(10-12-20)23(25)26/h3-14H,15-16H2,1-2H3,(H,25,26)
PubChem CID	25207451
ChEMBL	CHEMBL3978302
IUPHAR	N/A
BindingDB	211115
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	678.0 nM	N/A	BindingDB
IC50	678.0 nM	None	ChEMBL

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