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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3717785
Molecular formula	C23H14Cl2N4O3S2
IUPAC name	6-[6-chloro-4-[[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy]-1-benzofuran-2-yl]-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole
Molecular weight	529.41
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	6.7
Synonyms	US9688695, 188 BDBM176155 SCHEMBL15357296
Inchi Key	AAGYCSOFLAYZMI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H14Cl2N4O3S2/c1-30-23-28-29-9-17(27-22(29)34-23)20-8-16-18(6-14(25)7-19(16)32-20)31-10-15-11-33-21(26-15)12-2-4-13(24)5-3-12/h2-9,11H,10H2,1H3
PubChem CID	89879364
ChEMBL	CHEMBL3717785
IUPHAR	N/A
BindingDB	176155
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.85 nM	N/A	BindingDB
EC50	0.85 nM	, None	BindingDB,ChEMBL

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