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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesRattus norvegicus (Rat)
GeneHtr2a
Synonym5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
'D' receptor
5-HT-2A
serotonin receptor 2A
5Ht-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length471
Amino acid sequenceMEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProtP14842
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL322
IUPHAR6
DrugBankN/A

Ligand

NameCHEMBL3765273
Molecular formulaC19H23ClN4O
IUPAC nameN-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]pyridine-4-carboxamide
Molecular weight358.87
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.7
SynonymsBDBM50145606
Inchi KeyAFTMJYXQWBHMFW-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H23ClN4O/c20-17-3-1-4-18(15-17)24-13-11-23(12-14-24)10-2-7-22-19(25)16-5-8-21-9-6-16/h1,3-6,8-9,15H,2,7,10-14H2,(H,22,25)
PubChem CID127042640
ChEMBLCHEMBL3765273
IUPHARN/A
BindingDB50145606
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1380.0 nMPMID26820556BindingDB,ChEMBL

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