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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3741030
Molecular formulaC17H14ClN3O
IUPAC name4-[(2-chlorophenoxy)methyl]-6-methyl-2-pyridin-2-ylpyrimidine
Molecular weight311.769
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.4
SynonymsJ3.528.994A
2-(2-Pyridyl)-4-(2-chlorophenoxy)methyl-6-methylpyrimidine
Inchi KeyAMZUNHSQKCBELL-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H14ClN3O/c1-12-10-13(11-22-16-8-3-2-6-14(16)18)21-17(20-12)15-7-4-5-9-19-15/h2-10H,11H2,1H3
PubChem CID127040388
ChEMBLCHEMBL3741030
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50316.23 nMMedChemComm, (2015) 6:6:1024ChEMBL

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