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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesRattus norvegicus (Rat)
GeneHtr1a
Synonym5-HT1A receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
5-HT1A
ADRB2RL1
ADRBRL1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length422
Amino acid sequenceMDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProtP19327
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL273
IUPHAR1
DrugBankN/A

Ligand

NameCHEMBL3741553
Molecular formulaC24H28FN3O3S
IUPAC name3-[1-[[1-(benzenesulfonyl)piperidin-4-yl]methyl]piperidin-4-yl]-6-fluoro-1,2-benzoxazole
Molecular weight457.564
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP4.0
SynonymsJ3.517.043J
(4'-(6-Fluoro-1,2-benzoisoxazole-3-yl)-[4,1'-methylenebis(piperidine)]-1-yl)phenyl sulfone
Inchi KeyAOLAMVAYRSUIEG-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H28FN3O3S/c25-20-6-7-22-23(16-20)31-26-24(22)19-10-12-27(13-11-19)17-18-8-14-28(15-9-18)32(29,30)21-4-2-1-3-5-21/h1-7,16,18-19H,8-15,17H2
PubChem CID127042414
ChEMBLCHEMBL3741553
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMMedChemComm, (2015) 6:5:831ChEMBL

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