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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3732437
Molecular formula	C28H24N4O5S
IUPAC name	2-methoxy-6-[6-methoxy-4-[[3-[(6-methylpyridin-2-yl)methoxy]phenyl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Molecular weight	528.583
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	5.5
Synonyms	SCHEMBL16707930
Inchi Key	AVWPQVHDNKHZTM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H24N4O5S/c1-17-6-4-8-19(29-17)16-35-20-9-5-7-18(10-20)15-36-24-11-21(33-2)12-25-22(24)13-26(37-25)23-14-32-27(30-23)38-28(31-32)34-3/h4-14H,15-16H2,1-3H3
PubChem CID	118068386
ChEMBL	CHEMBL3732437
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	9.23 nM	None	ChEMBL
IC50	101.0 nM	None	ChEMBL

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