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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL3800146
Molecular formula	C26H21Cl2N3O3S
IUPAC name	3-[[1-[3-(3,5-dichlorophenyl)-5-thiophen-2-ylpyrazol-1-yl]-2,3-dihydro-1H-indene-5-carbonyl]amino]propanoic acid
Molecular weight	526.432
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.3
Synonyms	BDBM50168094
Inchi Key	BAHMPQDACGDTIV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H21Cl2N3O3S/c27-18-11-17(12-19(28)13-18)21-14-23(24-2-1-9-35-24)31(30-21)22-6-4-15-10-16(3-5-20(15)22)26(34)29-8-7-25(32)33/h1-3,5,9-14,22H,4,6-8H2,(H,29,34)(H,32,33)
PubChem CID	127047255
ChEMBL	CHEMBL3800146
IUPHAR	N/A
BindingDB	50168094
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5300.0 nM	PMID27161876	BindingDB,ChEMBL
IC50	14500.0 nM	PMID27161876	BindingDB,ChEMBL

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