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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameSCHEMBL2505806
Molecular formulaC24H25NO2S
IUPAC name(1S,2S)-N-[(1R)-1-[4-(4-ethylphenyl)phenyl]-2-hydroxyethyl]-2-thiophen-2-ylcyclopropane-1-carboxamide
Molecular weight391.529
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP4.4
SynonymsCHEMBL3717862
Inchi KeyBAWUIVSQZHKYDH-FKBYEOEOSA-N
Inchi IDInChI=1S/C24H25NO2S/c1-2-16-5-7-17(8-6-16)18-9-11-19(12-10-18)22(15-26)25-24(27)21-14-20(21)23-4-3-13-28-23/h3-13,20-22,26H,2,14-15H2,1H3,(H,25,27)/t20-,21-,22-/m0/s1
PubChem CID51348365
ChEMBLCHEMBL3717862
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5062.0 nMNoneChEMBL

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