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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3717974
Molecular formula	C33H33N5O5S2
IUPAC name	N-(1-cyclopropylethyl)-4-[4-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]-1,3-thiazol-2-yl]-N-propylbenzamide
Molecular weight	643.777
Hydrogen bond acceptor	10
Hydrogen bond donor	0
XlogP	6.9
Synonyms	BDBM176280 SCHEMBL16603386 US9688695, 313
Inchi Key	BBOMGNKXFZPENL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C33H33N5O5S2/c1-5-12-37(19(2)20-6-7-20)31(39)22-10-8-21(9-11-22)30-34-23(18-44-30)17-42-27-13-24(40-3)14-28-25(27)15-29(43-28)26-16-38-32(35-26)45-33(36-38)41-4/h8-11,13-16,18-20H,5-7,12,17H2,1-4H3
PubChem CID	117981595
ChEMBL	CHEMBL3717974
IUPHAR	N/A
BindingDB	176280
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.43 nM	N/A	BindingDB
EC50	0.43 nM	, None	BindingDB,ChEMBL

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