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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	N,N-Di-n-propylserotonin
Molecular formula	C16H24N2O
IUPAC name	3-[2-(dipropylamino)ethyl]-1H-indol-5-ol
Molecular weight	260.381
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	3.0
Synonyms	36288-75-2 CTK4H6243 PDSP2_000753 1H-Indol-5-ol, 3-(2-(dipropylamino)ethyl)- AC1L54DG 3-(2-Dipropylamino-ethyl)-1H-indol-5-ol(DiPS) PDSP1_000765 5-Hydroxy-N,N-dipropyltryptamine DTXSID80189827 SCHEMBL8891077 1H-Indol-5-ol,3-[2-(dipropylamino)ethyl]- AC1Q7A16 N,N-dipropylserotonin 3-[2-(dipropylamino)ethyl]-1h-indol-5-ol CHEMBL141706 PDSP2_000013 N,N-Di-n-propyl-2-((5-hydroxyindol-3-yl)amino)ethane ZINC5832849 3-(2-Dipropylamino-ethyl)-1H-indol-5-ol BDBM50020702 PDSP1_000013 [ Show all ]
Inchi Key	CWMOGUBWVJQDSL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H24N2O/c1-3-8-18(9-4-2)10-7-13-12-17-16-6-5-14(19)11-15(13)16/h5-6,11-12,17,19H,3-4,7-10H2,1-2H3
PubChem CID	169764
ChEMBL	CHEMBL141706
IUPHAR	N/A
BindingDB	50020702
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	820.0 nM	PMID8941384	BindingDB,ChEMBL

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