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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3805558
Molecular formulaC18H14ClN3O3S
IUPAC name3-[5-[[3-(3-chlorophenyl)phenyl]carbamoyl]-1,3,4-thiadiazol-2-yl]propanoic acid
Molecular weight387.838
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP3.6
SynonymsBDBM50171871
Inchi KeyBFPHGTJOAXVIST-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H14ClN3O3S/c19-13-5-1-3-11(9-13)12-4-2-6-14(10-12)20-17(25)18-22-21-15(26-18)7-8-16(23)24/h1-6,9-10H,7-8H2,(H,20,25)(H,23,24)
PubChem CID127048843
ChEMBLCHEMBL3805558
IUPHARN/A
BindingDB50171871
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501690.0 nMPMID27229618BindingDB,ChEMBL

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