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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3719375
Molecular formulaC31H28N4O7S2
IUPAC namemethyl 4-[4-[4-[[6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-benzofuran-4-yl]oxymethyl]-1,3-thiazol-2-yl]oxan-4-yl]benzoate
Molecular weight632.706
Hydrogen bond acceptor12
Hydrogen bond donor0
XlogP5.7
SynonymsBDBM176127
SCHEMBL15349026
US9688695, 160
Inchi KeyBFSKCTYEANSQMB-UHFFFAOYSA-N
Inchi IDInChI=1S/C31H28N4O7S2/c1-37-21-12-24(22-14-26(42-25(22)13-21)23-15-35-29(33-23)44-30(34-35)39-3)41-16-20-17-43-28(32-20)31(8-10-40-11-9-31)19-6-4-18(5-7-19)27(36)38-2/h4-7,12-15,17H,8-11,16H2,1-3H3
PubChem CID89873005
ChEMBLCHEMBL3719375
IUPHARN/A
BindingDB176127
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC500.5 nMNoneChEMBL
EC500.5 nMN/ABindingDB

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