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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL3797955 |
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Molecular formula | C23H23ClN6O3 |
IUPAC name | 6-[(2S)-2-[5-chloro-3-[(6-methoxy-2,5-dimethylpyridin-3-yl)amino]-2-oxopyrazin-1-yl]-2-cyclopropylethoxy]pyridine-3-carbonitrile |
Molecular weight | 466.926 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 3.1 |
Synonyms | N/A |
Inchi Key | BITICEVAOACCIQ-GOSISDBHSA-N |
Inchi ID | InChI=1S/C23H23ClN6O3/c1-13-8-17(14(2)27-22(13)32-3)28-21-23(31)30(11-19(24)29-21)18(16-5-6-16)12-33-20-7-4-15(9-25)10-26-20/h4,7-8,10-11,16,18H,5-6,12H2,1-3H3,(H,28,29)/t18-/m1/s1 |
PubChem CID | 127047691 |
ChEMBL | CHEMBL3797955 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 7.7 nM | PMID27020524 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218