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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3800255
Molecular formulaC25H28FNO5
IUPAC name3-[4-[[3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-(2-methylpropoxy)phenyl]methoxy]-2-fluorophenyl]propanoic acid
Molecular weight441.499
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP5.4
SynonymsBDBM50165152
Inchi KeyBJMZEBLXIDSJDR-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H28FNO5/c1-15(2)13-30-22-10-18(9-20(11-22)25-16(3)27-32-17(25)4)14-31-21-7-5-19(23(26)12-21)6-8-24(28)29/h5,7,9-12,15H,6,8,13-14H2,1-4H3,(H,28,29)
PubChem CID127046662
ChEMBLCHEMBL3800255
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50143.0 nMPMID27054485ChEMBL
Emax102.0 %PMID27054485ChEMBL

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