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Name | Metabotropic glutamate receptor 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | GRM4 |
Synonym | mGluR4 mGlu4 receptor GPRC1D glutamate receptor |
Disease | Anxiety disorder Neurological disease |
Length | 912 |
Amino acid sequence | MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI |
UniProt | Q14833 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T99402 |
ChEMBL | CHEMBL2736 |
IUPHAR | 292 |
DrugBank | BE0000833 |
Name | CHEMBL3809928 |
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Molecular formula | C16H12FN3O3S |
IUPAC name | N-[1-(4-fluorophenyl)sulfonylpyrrol-3-yl]pyridine-2-carboxamide |
Molecular weight | 345.348 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 2.1 |
Synonyms | BDBM50176352 SCHEMBL14700770 |
Inchi Key | BJRKRJUIRNGBEK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H12FN3O3S/c17-12-4-6-14(7-5-12)24(22,23)20-10-8-13(11-20)19-16(21)15-3-1-2-9-18-15/h1-11H,(H,19,21) |
PubChem CID | 52914100 |
ChEMBL | CHEMBL3809928 |
IUPHAR | N/A |
BindingDB | 50176352 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
%max | 78.8 % | PMID27234146 | ChEMBL |
EC50 | 740.0 nM | PMID27234146 | BindingDB,ChEMBL |
EC50 | 741.0 nM | PMID27234146 | BindingDB |
EC50 | 741.31 nM | PMID27234146 | ChEMBL |
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