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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameSCHEMBL3450989
Molecular formulaC20H17NO4S
IUPAC name2-[6-[(2-phenyl-1,3-thiazol-4-yl)methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid
Molecular weight367.419
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP3.4
SynonymsCHEMBL3781314
Inchi KeyBNZSYMKLXOOXNY-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H17NO4S/c22-19(23)8-14-10-25-18-9-16(6-7-17(14)18)24-11-15-12-26-20(21-15)13-4-2-1-3-5-13/h1-7,9,12,14H,8,10-11H2,(H,22,23)
PubChem CID23111759
ChEMBLCHEMBL3781314
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.15 %PMID26945112ChEMBL
Activity5.67 %PMID26945112ChEMBL

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