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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3780732
Molecular formulaC30H29NO5
IUPAC name2-[6-[[3-(2,5-dimethylpyrrol-1-yl)-4-phenylmethoxyphenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid
Molecular weight483.564
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.3
SynonymsN/A
Inchi KeyBQKBCTUZBLGRIT-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H29NO5/c1-20-8-9-21(2)31(20)27-14-23(10-13-28(27)35-17-22-6-4-3-5-7-22)18-34-25-11-12-26-24(15-30(32)33)19-36-29(26)16-25/h3-14,16,24H,15,17-19H2,1-2H3,(H,32,33)
PubChem CID127031697
ChEMBLCHEMBL3780732
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity40.75 %PMID27020683ChEMBL

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