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Name | Metabotropic glutamate receptor 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | GRM4 |
Synonym | mGluR4 mGlu4 receptor GPRC1D glutamate receptor |
Disease | Anxiety disorder Neurological disease |
Length | 912 |
Amino acid sequence | MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI |
UniProt | Q14833 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T99402 |
ChEMBL | CHEMBL2736 |
IUPHAR | 292 |
DrugBank | BE0000833 |
Name | CHEMBL3800579 |
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Molecular formula | C20H12ClN3O4 |
IUPAC name | N-[3-chloro-4-(1,3-dioxoisoindol-2-yl)phenyl]-3-hydroxypyridine-2-carboxamide |
Molecular weight | 393.783 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 3.4 |
Synonyms | BDBM50166954 |
Inchi Key | BQTFLGSTZRWVCK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H12ClN3O4/c21-14-10-11(23-18(26)17-16(25)6-3-9-22-17)7-8-15(14)24-19(27)12-4-1-2-5-13(12)20(24)28/h1-10,25H,(H,23,26) |
PubChem CID | 127047649 |
ChEMBL | CHEMBL3800579 |
IUPHAR | N/A |
BindingDB | 50166954 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
%max | 115.4 % | PMID27131990 | ChEMBL |
EC50 | 125.0 nM | PMID27131990 | BindingDB,ChEMBL |
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